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By the Hyde Park Pharmacy pharmacist team · Hyde Park Pharmacy, 22–24 Woodsley Road, Leeds LS3 1DT · Last updated 19 August 2026

A couple in their 40s laughing together over coffee at their kitchen table in warm morning light

ED treatment: a pharmacist compares every option

By the Hyde Park Pharmacy pharmacist team · Published 19 August 2026 · 9 min read

Around half of men aged 40–70 experience some degree of erectile difficulty — it is one of the most common conditions we see, and still the one men are least likely to raise with anyone. Two facts are worth holding before anything else: for most men ED is very treatable, and occasionally it is the first visible sign of something else that deserves a check. This guide compares every option we offer — honestly, including the tablet-free ones — and explains what safe, legitimate supply looks like, because ED medicines are among the most counterfeited in the world.

First: why new ED is worth taking seriously

An erection is a vascular event — it depends on healthy blood flow. That is why new or worsening ED, particularly in your 40s and 50s, can occasionally be an early indicator of cardiovascular disease, diabetes or low testosterone, sometimes years before other symptoms. This is not a reason to panic; it is a reason not to buy tablets from an unregulated website and ignore the question. Any good consultation — ours included — asks about heart health, blood pressure and your other medicines precisely because of this link. If your ED is new, changing, or comes with other symptoms, a conversation with your GP about underlying causes is worth having alongside treatment.

The tablets, honestly compared

All the main ED tablets belong to one family — PDE5 inhibitors — and work the same way: they improve blood flow in response to arousal. They do not cause an erection on their own and do not change desire. NHS prescribing guidance treats sildenafil, tadalafil and vardenafil as probably equally effective, so the real choice is about timing, duration and how your body responds. Around 60–70% of men respond to a PDE5 inhibitor; in trials, sildenafil produced effective erections in 77–84% of attempts at the 50–100 mg doses. If the first tablet disappoints at the right dose, switching to a different one is evidence-based practice, not wishful thinking.

How long each tablet keeps working
The window in which the medicine can support an erection — not how long an erection lasts.
Sildenafil~4 hours · take about 1 hour before · heavy meals delay it
Vardenafil~4–5 hours · a genuine alternative if sildenafil disappoints
Tadalafilup to 36 hours · food doesn’t interfere — the “weekend” option
Durations from each medicine’s UK licence (SmPC). Branded and generic versions of the same medicine share the same active ingredient and the same window.

Brand or generic — what actually differs

Viagra®, Cialis® and Levitra® are the original brands of sildenafil, tadalafil and vardenafil. The generic versions are therapeutically equivalent — same active ingredient, same licensing standards — at a fraction of the price, which is why UK guidance treats generic sildenafil as the usual first choice. Some men simply prefer the manufacturer’s own pack, and we stock both routes. There are also pharmacy-medicine (P) versions that need no prescription at all — Viagra Connect® and its Melts film (sildenafil 50 mg), the pharmacy generic sildenafil, and the pharmacy tadalafils Cialis Together® and Avarante® (10 mg) — supplied after a shorter pharmacist suitability check rather than a prescription-level consultation.

Compare all ED treatments

Every option we supply, side by side. Same active ingredient = same medicine; the brand is your choice.

SildenafilLowest-cost optionViagra®The original brandViagra Connect®Pharmacy medicine (P)TadalafilWorks up to 36 hoursCialis®The original 36-hour brandVardenafilFast onsetLevitra®The original brand
PackSildenafil packViagra® packViagra Connect® packTadalafil packCialis® packVardenafil packLevitra® pack
Prices from
per tablet
from £2.50 per tabletfrom £7.50 per tabletfrom £4.50 per tabletfrom £5.00 per tabletfrom £10.00 per tabletfrom £7.50 per tabletfrom £5.99 per tablet
Active ingredientSildenafilSildenafilSildenafilTadalafilTadalafilVardenafilVardenafil
When to take itAbout 1 hour beforeAbout 1 hour beforeAbout 1 hour before30–60 min before · up to 36 h window30–60 min before · up to 36 h window25–60 min before25–60 min before
View treatment →View treatment →View treatment →View treatment →View treatment →View treatment →View treatment →

Timings are from each medicine’s SPC. Generic and branded versions contain the same active ingredient and are therapeutically equivalent — our pharmacist confirms what’s suitable at your free consultation. Images are for illustration purposes only — generic brand may vary.

Not every option is a tablet

Two of our options involve no medicine entering the bloodstream at all. Eroxon® StimGel is a topical gel that works within about 10 minutes and is a general-sale product — no prescription and no consultation needed. A vacuum erection device (we stock the VaxAid® Deluxe) is a drug-free, clinically recognised option — often the right answer where tablets aren’t suitable, for example alongside nitrate heart medicines. Neither is a lesser choice; they are different tools for different situations.

The safety questions a pharmacist always asks

Before any supply, we check for nitrate medicines (GTN spray, isosorbide) and nicorandil — combining them with any PDE5 inhibitor can cause a dangerous drop in blood pressure — plus recent heart events, interacting medicines, and whether the requested dose is the right starting point. Legitimate services ask these questions every time; a site that will sell you ED tablets without a single health question is not a shortcut, it is the warning sign.

How pharmacist-led supply works
The same clinical check, whichever option you choose — you pay at checkout, and no money is kept if it isn’t approved.
1 · Questionnaire
A structured, confidential health check — about 5 minutes, online or in person. No video call.
2 · Pharmacist review
A named GPhC pharmacist personally reviews your answers — no automatic approvals.
3 · Supply or refund
Approved: discreet plain-packaged delivery or collection. Not appropriate: a full refund and honest advice on the right route.
Our GPhC registration is 9011727 — you can check any UK pharmacy on the public GPhC register before buying anything.

How to spot a counterfeit seller in under a minute

ED tablets are among the most faked medicines sold online — wrong doses, no active ingredient, or worse. Two checks: a legitimate UK online pharmacy displays its GPhC registration number (look it up on the GPhC register — ours is 9011727), and it will always run a health questionnaire before supplying medicine. No questionnaire and no registration number? Close the tab.

Questions we hear at the counter

Do the tablets work for everyone?
No — around 60–70% of men respond to a PDE5 inhibitor. If the first one doesn’t work at the right dose taken correctly (timing, food), trying a different one is evidence-based. If none work, that itself is useful clinical information worth discussing with your GP.
Can I drink alcohol with them?
Small amounts are usually fine. Heavier drinking works against the medicine physiologically — alcohol is one of the most common reasons a tablet “didn’t work”.
Are they safe to use long term?
Used as directed, with interactions screened, PDE5 inhibitors have a long safety record. The review that matters is keeping the underlying-cause question open — especially heart health.
What if I’d rather not take tablets at all?
Lifestyle changes genuinely help — the same things that protect your heart protect erections. And the gel and vacuum-device options above are entirely tablet-free.

Where to get treatment

Our pharmacist can check what suits you. Every treatment is supplied only after a pharmacy consultation confirms it is appropriate.

Sildenafil (generic Viagra) →Tadalafil (generic Cialis) →Vardenafil (generic Levitra) →Viagra® (branded sildenafil) →Cialis® (branded tadalafil) →Levitra® (branded vardenafil) →Cialis Together® (pharmacy tadalafil) →Viagra Connect →Viagra Connect Melts →Sildenafil Perrigo →Avarante →Eroxon Stimgel →VaxAid Deluxe →Erectile Dysfunction treatments →
This article is general information from our pharmacist team, not personal medical advice, and it does not replace the patient information leaflet supplied with your medicine — always read the leaflet in your own pack. ED treatments range from general-sale products to prescription-only medicines; every supply is checked by the pharmacist for suitability. If you take nitrate medicines or have recent heart problems, speak to your GP or cardiologist about ED treatment. If chest pain occurs during sexual activity, stop and call 999.

Sources: NHS prescribing guidance on erectile dysfunction (sildenafil, tadalafil and vardenafil treated as probably equally effective; generic sildenafil first-line); NICE Clinical Knowledge Summaries, erectile dysfunction; UK SmPCs for sildenafil, tadalafil (window up to 36 hours) and vardenafil at medicines.org.uk; PDE5-inhibitor response rates from published meta-analysis (60–70%; sildenafil 77–84% at 50–100 mg). Read August 2026.

Sources & further reading

  1. NHS — Erection problems (erectile dysfunction)
  2. NICE CKS — Erectile dysfunction